Remeron (Mirtazapine) is a SNDI, a serotonin norepinephrine disinhibitor. It blocks the receptors that normally inhibit norepinephrine and serotonin. This is an interesting one to me! It is the only drug in this specific class. It has both antianxiety and antidepressive effects, and its antidepressive effects may actually occur faster than SSRIs. Remeron is also an antidote to sexual dysfunction secondary to use of SSRIs.
Side effects include sedation that is increased by use of alcohol, benzos, and other CNS depressants. *Teach your patients about this! Do not use with MAOIs either. Major thing to note: typical increase in appetite, weight gain, and cholesterol with the use of Remeron.
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